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Non-randomised trial, 2008

Can the Sheehan Disability Scale measure whether treatments work?

Yes. The scale was able to tell the difference between treatments that worked and treatments that didn't in clinical trials.

Strong study design Patients in clinical trials (37 studies) for anxiety, depression, or PMDD

What they did

Review of clinical trials using the Sheehan Disability Scale to measure functional disability in work, social, and family life. They searched PubMed from 1966 to March 2007 and included only double-blind controlled or large open-label trials treating anxiety, depression, or PMDD.

What they found

37 studies met inclusion criteria. All treated the scale as numeric and analyzed mean change scores. The scale performed well at discriminating between active treatments and inactive treatments, showing it is sensitive to treatment effects.

What it means for you

The Sheehan Disability Scale is a useful tool for measuring whether psychiatric treatments improve functional problems at work and home. The review is limited to published trials in English and from relatively recent decades.

37

studies reviewed

1966-2007

publication date range searched

About the study

Original title
Assessing treatment effects in clinical trials with the discan metric of the Sheehan Disability Scale
Authors
Sheehan KH, Sheehan DV
Journal
International clinical psychopharmacology
Year
2008
Study design
Non-randomised trial
Participants
20
What was tested
Various psychiatric treatments (measured by Sheehan Disability Scale)

Topics