Survey study, 2014
Can measuring a protein in blood cells help diagnose PMDD?
Lower levels of a protein called beta-arrestin1 were found in women with PMDD, and the reduction was correlated with more severe depression symptoms, suggesting this measurement could help diagnose PMDD.
What they did
Non-pregnant women aged 18-42 with PMS or PMDD symptoms at the luteal phase (not taking antidepressants) were studied. Beta-arrestin1 protein in their blood cells was measured and compared with depression severity scores.
What they found
Women with depression (PMDD) had significantly lower beta-arrestin1 protein levels compared to those without depression. The reduction in beta-arrestin1 was significantly correlated with the severity of depressive symptoms.
What it means for you
Beta-arrestin1 measurements might be useful as a blood test to help diagnose PMDD and support questionnaire results. The study does not clearly state how many women were included.
18-42
Age range (years)
Luteal phase
Study timing
About the study
- Original title
- Correlation of beta‐arrestin1 levels in mononuclear leukocytes with depression scores for women with premenstrual dysphoric disorder (1144.2)
- Authors
- Tultul Nayyar, Farzana Alam, William D. Richie et al.
- Journal
- The FASEB Journal
- Year
- 2014
- Study design
- Survey study
- What was tested
- None
- Read the paper
- doi.org/10.1096/fasebj.28.1_supplement.1144.2
Topics
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