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Case report, 1998

Which hormonal treatments work best for premenstrual syndrome?

Estrogen is clearly effective. Progesterone does not work and might even worsen symptoms. Birth control pills help because they contain estrogen.

Early or limited evidence Literature review of hormonal therapy studies.

What they did

The authors described one case of successful hormonal treatment and reviewed studies on how hormonal treatments work for PMS.

What they found

Estrogen clearly relieves PMS symptoms. Progesterone is ineffective and might worsen symptoms. Combination oral contraceptives are effective because of their estrogen content. There is limited research comparing different birth control pills for PMS. Depression symptoms may not respond to hormonal treatment, and antidepressants might work better.

What it means for you

Estrogen appears most effective for hormone-based PMS treatment. The main limit is that this is a review of existing studies, not a new study, and research comparing different pills is still limited.

About the study

Original title
Hormonal therapy in the management of premenstrual syndrome
Authors
Tiemstra JD, Patel K
Journal
The Journal of the American Board of Family Practice
Year
1998
Study design
Case report
What was tested
Hormonal treatments: estrogen, progesterone, and oral contraceptives.
Open access
Yes

Topics