Case-control study, 1998
Do women with PMS have abnormal growth hormone levels like women with depression?
No, levels of IGF-1 and IGFBP-3 did not differ between women with PMS and controls, suggesting PMS and depression have different biological causes.
What they did
Prospective case-control study of 32 women with PMS and 32 asymptomatic controls who kept daily symptom diaries and completed depression screening. Blood samples were taken 5 and 12 days after the LH surge was detected using a urinary LH kit.
What they found
Levels of IGF-1, IGFBP-3, estrogen, and progesterone did not differ between women with PMS and control subjects.
What it means for you
Even though PMS and depression share similar symptoms, this study suggests they may have different biological causes. The study had a reasonable sample size and prospective design, but it only measured one hormone system and tested at two specific time points.
32
Women with PMS
32
Asymptomatic controls
5 and 12
Days after LH surge when blood samples taken
About the study
- Original title
- Insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 in women with premenstrual syndrome
- Authors
- Rapkin AJ, Cedars M, Morgan M et al.
- Journal
- Fertility and sterility
- Year
- 1998
- Study design
- Case-control study
- Participants
- 32
- What was tested
- None (observational hormone measurement study)
- Open access
- Yes
- Read the paper
- doi.org/10.1016/s0015-0282(98)00389-6
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