Cohort study, 2022
Do women with both bipolar disorder and PMDD have worse biological rhythm disruptions?
Yes, women with both bipolar disorder and PMDD experienced greater disruptions in biological rhythms across both the follicular and luteal phases of the menstrual cycle, especially in sleep and activity patterns.
What they did
Two studies assessed biological rhythm disruptions. The first surveyed 727 women using a questionnaire about daily rhythms. The second followed 77 outpatient women and assessed them during mid-follicular and late-luteal phases. Both groups included women with PMDD only, bipolar disorder only, both conditions, and controls.
What they found
In the population-based sample, all three diagnostic groups showed greater biological rhythm disruption than controls, with bipolar disorder showing the most disruption. In the outpatient sample, women with both PMDD and bipolar disorder reported significantly greater rhythm disruption in social domains than women with PMDD alone, and reported disruptions across both follicular and luteal phases.
What it means for you
Having both bipolar disorder and PMDD creates additional biological rhythm problems that extend beyond the premenstrual period. The study relies on questionnaire responses rather than objective measurements, and results may not apply to all populations.
727
Women in population-based sample
77
Women in outpatient study
24
Women with both PMDD and bipolar disorder
About the study
- Original title
- Investigating biological rhythms disruptions across the menstrual cycle in women with comorbid bipolar disorder and premenstrual dysphoric disorder
- Authors
- El Dahr Y, de Azevedo Cardoso T, Syan SK et al.
- Journal
- Archives of women's mental health
- Year
- 2022
- Study design
- Cohort study
- Participants
- 727
- What was tested
- None; observational study using biological rhythm questionnaire at two time points
- Open access
- Yes
- Read the paper
- doi.org/10.1007/s00737-022-01220-0
Topics
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