Cohort study, 1993
Is low serotonin sensitivity a permanent trait in PMDD?
Women with PMDD showed blunted serotonin responses during their follicular phase, suggesting low serotonin sensitivity may be a constant trait rather than only occurring before the period.
What they did
7 women with PMDD and 7 control women received a serotonin challenge test (buspirone) during their follicular phase. Researchers measured prolactin responses to assess serotonin system function.
What they found
Women with PMDD had blunted prolactin responses to buspirone during the follicular phase.
What it means for you
Low serotonin sensitivity may be an ongoing feature of PMDD, but this was a very small pilot study that needs confirmation.
7
Women per group
Follicular
Phase tested
About the study
- Original title
- Is 5HT1A receptor subsensitivity a trait marker for late luteal phase dysphoric disorder? A pilot study
- Authors
- Yatham LN
- Journal
- Canadian journal of psychiatry. Revue canadienne de psychiatrie
- Year
- 1993
- Study design
- Cohort study
- What was tested
- Buspirone serotonin challenge test
- Read the paper
- doi.org/10.1177/070674379303801007
Topics
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