Review, 1999
Is premenstrual dysphoric disorder a distinct clinical disorder?
Yes, according to expert consensus. PMDD has distinct characteristics, clear symptoms linked to the menstrual cycle, and responds differently to treatment than other mood disorders.
What they did
Roundtable discussion where expert panel reviewed evidence about PMDD and compared it to known mood and anxiety disorders.
What they found
At least 60 percent of PMDD patients respond to selective serotonin reuptake inhibitors. PMDD has clear onset and offset of symptoms closely tied to the menstrual cycle with prominent anger, irritability, and internal tension. Symptoms remain stable cycle to cycle. PMDD differs from mood disorders in how the body handles serotonin and has genetic factors not found in major depression.
What it means for you
PMDD is a separate condition from depression and anxiety, which matters for correct diagnosis and treatment. This is a discussion of expert opinion, not original research data, which is a limitation.
60%
PMDD patients responding to SSRIs
About the study
- Original title
- Is premenstrual dysphoric disorder a distinct clinical entity?
- Authors
- Endicott J, Amsterdam J, Eriksson E et al.
- Journal
- Journal of women's health & gender-based medicine
- Year
- 1999
- Study design
- Review
- What was tested
- Selective serotonin reuptake inhibitors
- Read the paper
- doi.org/10.1089/jwh.1.1999.8.663
Topics
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