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Cohort study, 1997

Does pain sensitivity change across the menstrual cycle?

Ischemic pain sensitivity (pain from blocked blood flow) increases after ovulation, but heat pain does not change with the cycle. The study was very small.

Early or limited evidence 11 healthy women

What they did

11 healthy women were tested at three menstrual cycle phases (after menstruation, during ovulation, and in the late cycle). Researchers measured pain responses to heat and to blocked blood flow, and measured hormone levels and tracked physical and emotional symptoms.

What they found

Women felt less pain from blocked blood flow in the early phase after menstruation, but more pain during ovulation and the late cycle. Heat pain did not vary across the cycle.

What it means for you

Ischemic pain sensitivity is higher after ovulation, possibly linked to hormone changes. This study is limited by a very small sample size of 11 women.

11

women studied

3

menstrual cycle phases tested

About the study

Original title
Ischemic but not thermal pain sensitivity varies across the menstrual cycle
Authors
Fillingim RB, Maixner W, Girdler SS et al.
Journal
Psychosomatic medicine
Year
1997
Study design
Cohort study
Participants
11
What was tested
Observation across menstrual cycle phases

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