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Case report, 2013

Does lamotrigine help when antidepressants don't work well enough for severe PMDD?

One woman with severe PMDD significantly improved when lamotrigine was added to her antidepressant. This is one person's experience, so we can't be sure it would work for everyone.

Early or limited evidence One 42-year-old woman with severe PMDD

What they did

Doctors treated one 42-year-old woman with severe PMDD that wasn't controlled well enough with an antidepressant (SSRI) alone. They added lamotrigine, another mood medication.

What they found

She significantly improved after the lamotrigine was added to her treatment.

What it means for you

This is one woman's experience. It suggests lamotrigine might help when antidepressants don't work well enough for severe PMDD, but larger studies are needed to know for sure.

42 years old

age of patient

About the study

Original title
Lamotrigine augmentation in premenstrual dysphoric disorder: a case report
Authors
Sepede G, Martinotti G, Gambi F et al.
Journal
Clinical neuropharmacology
Year
2013
Study design
Case report
What was tested
Lamotrigine added to SSRI (antidepressant) treatment

Topics