Survey study, 2008
Do women with PMDD have different growth factors than other women?
Yes, women with PMDD had significantly lower insulin-like growth factor-1 levels throughout their menstrual cycle (205.7 vs 240.2 ng/mL, P=.01).
What they did
Measured bone and growth metabolism markers in women with PMDD and women without PMDD. Participants tracked symptoms for 2 months and had hormone testing for 1 month.
What they found
Women with PMDD had significantly lower serum insulin-like growth factor-1 (mean 205.7 ± 56.8 ng/mL) compared with controls (240.2 ± 76.9 ng/mL, P=.01). This lower level was consistent throughout all 5 phases of the menstrual cycle in the PMDD group.
What it means for you
Low growth factor may be part of the biological difference in PMDD, offering insight into why some women develop PMDD. Does not prove it causes PMDD. Sample size not specified for each group.
205.7 ng/mL
PMDD group IGF-1
240.2 ng/mL
control group IGF-1
P=.01
statistical significance
About the study
- Original title
- Lower insulin-like growth factor-1 concentrations in women with premenstrual dysphoric disorder
- Authors
- Thys-Jacobs S, McMahon D, Bilezikian JP
- Journal
- American journal of obstetrics and gynecology
- Year
- 2008
- Study design
- Survey study
- What was tested
- None; measurement of blood markers only.
- Read the paper
- doi.org/10.1016/j.ajog.2007.11.005
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