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Non-randomised trial, 2008

Does stress affect memory differently depending on menstrual cycle phase?

Stress had no clear effect on how well women remembered information at any menstrual cycle phase. However, in the mid-luteal phase when progesterone is highest, there was a stronger relationship between stress hormone levels and memory.

Early or limited evidence Women at different menstrual cycle phases

What they did

Tested women at three different menstrual cycle phases to see whether acute stress (created by putting their hand in ice water) affected memory performance. Women learned information, had stress applied, and were tested on memory recall one week later. Researchers measured both stress hormone levels and memory performance.

What they found

Stress did not significantly affect memory recall in any menstrual cycle phase. However, the relationship between cortisol (stress hormone) and memory recall differed by phase. In the mid-luteal phase, higher cortisol was associated with better memory one week later, whereas no such relationship existed in the follicular phase. Cortisol levels were higher during the mid-luteal phase.

What it means for you

Menstrual cycle hormones affect how stress hormones relate to memory, but this did not translate to measurable changes in how much women actually remembered. The practical significance of this relationship is unclear from this small study.

3

Menstrual cycle phases tested

1 week

Time to memory test after learning

About the study

Original title
Menstrual cycle modulation of the relationship between cortisol and long-term memory
Authors
Andreano JM, Arjomandi H, Cahill L
Journal
Psychoneuroendocrinology
Year
2008
Study design
Non-randomised trial
What was tested
Acute stress using cold water immersion

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