Case report, 1999
Can a GnRH analogue stop premenstrual attacks of hereditary coproporphyria?
Yes. In this one woman, the GnRH analogue stopped her menstrual cycle and her symptoms got much better. She has had only a minor attack once in 5 years but developed weaker bones.
What they did
Case report of a 20-year-old woman with hereditary coproporphyria. She needed frequent hospitalization due to premenstrual attacks. She was given intranasal buserelin acetate, a GnRH analogue that stops menstrual cycles.
What they found
Her symptoms improved dramatically once she stopped having periods. Urinary porphyrin derivatives fell markedly. She remained free from major attacks but had a minor attack once in 5 years. Her bones became weaker (osteopenia) as a side effect of long-term treatment.
What it means for you
Stopping the menstrual cycle with this hormone medicine can improve symptoms. However, long-term use can weaken bones, which is a concern. This is one woman's experience.
20
age in years
once in 5 years
frequency of minor attacks after treatment
About the study
- Original title
- Prevention of premenstrual exacerbation of hereditary coproporphyria by gonadotropin-releasing hormone analogue
- Authors
- Yamamori I, Asai M, Tanaka F et al.
- Journal
- Internal medicine (Tokyo, Japan)
- Year
- 1999
- Study design
- Case report
- What was tested
- Intranasal buserelin acetate (GnRH analogue)
- Open access
- Yes
- Read the paper
- doi.org/10.2169/internalmedicine.38.365
Topics
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