Survey study, 2024
Is the PvuII-ESR1 gene variant linked to PMDD in South Indian women?
No. The study found no significant association between this specific gene variant and PMDD.
What they did
Genetic study in South India. Researchers recruited 35 women with PMDD and 35 control women aged 18-45 from clinic visitors. Participants completed a validated screening questionnaire and provided blood samples for genetic testing.
What they found
The PvuII-ESR1 gene variant was present in both PMDD and control groups at similar rates. No significant association between the variant and PMDD. The screening questionnaire successfully distinguished women with PMDD from controls.
What it means for you
This particular gene variant does not explain PMDD risk, at least in this population. The gene's overall role in PMDD remains unclear. Findings are limited to South Indian women and may not apply to other populations.
35
women with PMDD
35
control women
About the study
- Original title
- PvuII-ESR1 gene polymorphism in premenstrual dysphoric disorder in South Indian women
- Authors
- Charmanna SO, Srinivas A, Prashant A et al.
- Journal
- Indian journal of psychiatry
- Year
- 2024
- Study design
- Survey study
- What was tested
- None (genetic analysis only)
- Open access
- Yes
Topics
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