Lab study, 1993
Do women with PMS have different chemicals in their urine?
Yes, women with PMS have lower levels of certain chemicals (prostaglandins and cyclic adenosine monophosphate) in their urine during the luteal phase.
What they did
Researchers collected urine samples during the luteal phase from 18 women with PMS and 18 healthy women. They measured levels of various chemicals that help control water and salt balance.
What they found
Women with PMS had lower levels of prostaglandin E2, prostaglandin F2 alpha, and cyclic adenosine monophosphate. Sodium, aldosterone, and kallikrein levels were similar in both groups.
What it means for you
This suggests the kidneys may handle water and other substances differently in women with PMS during the luteal phase, possibly explaining water retention. The study is small, so findings need confirmation in larger groups.
18
women with PMS
18
healthy women
About the study
- Original title
- Reduction in urinary prostaglandin excretion in the premenstrual syndrome
- Authors
- Piccoli A, Modena F, Calò L et al.
- Journal
- The Journal of reproductive medicine
- Year
- 1993
- Study design
- Lab study
- Participants
- 18
- Read the paper
- https://pubmed.ncbi.nlm.nih.gov/8120851/