Randomised trial, 2003
Does leptin explain why women develop PMS symptoms?
Probably not. Leptin levels did not change with successful PMS treatment, so leptin may not be the cause of PMS.
What they did
Randomized controlled study of 28 women with PMS and 20 without. Women with PMS received either leuprolide acetate 3.75 mg (injected once) plus tibolone 2.5 mg daily, or leuprolide plus placebo. Blood levels of leptin, estradiol, and progesterone were measured before and after 2 months of treatment.
What they found
Leptin levels did not differ between groups or change over time. Estradiol and progesterone dropped significantly during treatment. Before treatment, leptin correlated with estradiol and progesterone, but this link disappeared after treatment. All women with PMS improved significantly.
What it means for you
Leptin does not appear to explain why this PMS treatment works. The study was limited to one type of treatment and women in one country.
28
women with PMS
2.5 mg
tibolone daily dose
2
months of treatment
About the study
- Original title
- Serum leptin levels in patients with premenstrual syndrome treated with GnRH analogues alone and in association with tibolone
- Authors
- Tommaselli GA, Di Carlo C, Bifulco G et al.
- Journal
- Clinical endocrinology
- Year
- 2003
- Study design
- Randomised trial
- Participants
- 14
- What was tested
- Leuprolide 3.75 mg plus tibolone 2.5 mg daily versus leuprolide plus placebo
- Read the paper
- doi.org/10.1046/j.1365-2265.2003.01911.x
Topics
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