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Review, 2018

Can acoustic startle response help us understand how hormones affect PMDD?

Possibly. Two types of acoustic startle response tests may help scientists understand how hormones affect PMDD, but most studies have not yet properly tested this.

Early or limited evidence Review of research on women and sex differences in psychiatric disorders

What they did

This is a review examining whether the acoustic startle response, a simple test measuring how someone reacts to a sudden loud noise, could be used to study how hormone-like substances in the brain affect psychiatric disorders like PMDD.

What they found

Anxiety-potentiated startle and prepulse inhibition are the most reliable acoustic startle tests for studying how hormones affect mood disorders. However, few studies have actually tested whether these tests show differences related to the menstrual cycle or sex.

What it means for you

Scientists believe acoustic startle response tests might help understand how hormones affect mood disorders like PMDD, but this method is not yet widely used in research. The review identifies which test types might work best and recommends future studies account for hormone levels.

About the study

Original title
Startling Differences: Using the Acoustic Startle Response to Study Sex Differences and Neurosteroids in Affective Disorders
Authors
Hantsoo L, Golden CEM, Kornfield S et al.
Journal
Current psychiatry reports
Year
2018
Study design
Review
What was tested
None. This proposes acoustic startle response as a research method, not a treatment.
Open access
Yes

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