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Review, 2012

Should surgery be used to treat PMDD?

Surgery (removing both ovaries and uterus, followed by low-dose estrogen therapy) can be effective for PMDD, but only for women who don't respond to medications or cannot tolerate them.

Early or limited evidence Women of reproductive age with premenstrual mood disorders

What they did

Reviewed evidence on surgical treatment of PMDD, specifically oophorectomy (removing the ovaries) with concomitant hysterectomy (removing the uterus) followed by low-dose estrogen therapy.

What they found

Oophorectomy with concomitant hysterectomy followed by low-dose estrogen therapy was shown to be an effective alternative for women with menstrual-cycle-related mood disorder who fail medical treatment or cannot tolerate medications.

What it means for you

Surgery is a last resort for women who cannot tolerate or do not respond to medical treatments. The procedure is permanent and irreversible with significant risks, so should only be considered in severe cases after all other options are exhausted.

About the study

Original title
When should surgical treatment be considered for premenstrual dysphoric disorder?
Authors
Reid RL
Journal
Menopause international
Year
2012
Study design
Review
What was tested
Oophorectomy with hysterectomy followed by low-dose estrogen therapy

Topics