Survey study, 2005
Does drospirenone hormone therapy reduce weight gain and PMS-like symptoms?
In studies of drospirenone-containing hormone therapy, women had less or no weight gain (mean decrease of 1.2 kg after one year) and improvements in bloating, swelling, breast tenderness, and mood.
What they did
Review of clinical studies examining hormone therapies containing drospirenone. Studies measured effects on body weight and fluid-related symptoms.
What they found
Women on 1 mg estradiol with 2 mg drospirenone had mean body weight decrease of 1.2 kg after 1 year (p less than 0.001), compared to weight gain with estradiol alone. Improvements were seen in breast tenderness, swelling, abdominal bloating, skin changes, fatigue, and depressive mood.
What it means for you
Drospirenone may help prevent weight gain and improve fluid-related symptoms compared to other hormone therapies, which could improve quality of life. This review summarizes earlier studies but provides limited new primary evidence. A larger, more rigorous study would strengthen the findings.
1.2 kg
Mean weight decrease after 1 year
p < 0.001
Statistical significance
1 mg / 2 mg
Estradiol and drospirenone dose
About the study
- Original title
- Added benefits of drospirenone for compliance
- Authors
- Foidart JM
- Journal
- Climacteric : the journal of the International Menopause Society
- Year
- 2005
- Study design
- Survey study
- Participants
- 2
- What was tested
- Drospirenone-containing hormone therapies compared to other formulations.
- Read the paper
- doi.org/10.1080/13697130500330309
Topics
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