Randomised trial, 1994
Does alprazolam help women with late luteal phase dysphoric disorder?
Yes, but only for women whose symptoms happen only in the luteal phase. It reduced tension, irritability, and anxiety in that group but not in women who also had anxiety or depression at other times of the month.
What they did
Women took alprazolam and placebo for 3 months each in a crossover design. The study separated women into two groups: those with only LLPDD, and those with LLPDD plus anxiety or depression in other phases of the cycle.
What they found
In the first group, alprazolam significantly reduced tension, irritability, anxiety, and feelings of being out of control compared to placebo. Few side effects were reported. In the second group, alprazolam and placebo showed no difference.
What it means for you
Alprazolam helps only women with pure LLPDD, not those with ongoing mood symptoms. Side effects were dose-related.
0.25 mg
dose, three times daily
3 months
duration of each treatment phase
4
symptom types reduced
About the study
- Original title
- Alprazolam in the treatment of two subsamples of patients with late luteal phase dysphoric disorder: a double-blind, placebo-controlled crossover study
- Authors
- Berger CP, Presser B
- Journal
- Obstetrics and gynecology
- Year
- 1994
- Study design
- Randomised trial
- What was tested
- Alprazolam 0.25 mg three times daily
- Read the paper
- https://pubmed.ncbi.nlm.nih.gov/8058235/
Topics
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