Case-control study, 2010
Is a gene variant linked to PMDD?
No, this particular gene variant was not associated with PMDD. This does not rule out other genetic factors or that PMDD has a genetic basis.
What they did
The study compared a specific gene variant (rs25531) in women with diagnosed PMDD and healthy controls. They tested 53 women with PMDD and 52 controls and also tested a related gene variant.
What they found
There was no significant difference in the gene variant between the PMDD and control groups. Neither this variant alone nor combined with a related variant was associated with PMDD.
What it means for you
This particular gene variant does not appear to be a major factor in PMDD. However, this does not rule out other genetic factors. The study size was moderate, so larger studies might find different results.
53
Women with PMDD
52
Control women
37.7
Mean age of PMDD group
About the study
- Original title
- Analysis of the serotonin transporter promoter rs25531 polymorphism in premenstrual dysphoric disorder
- Authors
- Magnay JL, El-Shourbagy M, Fryer AA et al.
- Journal
- American journal of obstetrics and gynecology
- Year
- 2010
- Study design
- Case-control study
- Participants
- 53
- What was tested
- Gene variant testing (genotyping)
- Read the paper
- doi.org/10.1016/j.ajog.2010.02.043
Topics
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