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Survey study, 2023

Do inflammation markers in the blood link to food cravings during the menstrual cycle?

Yes, higher inflammation markers were linked to increased risk of moderate to severe food cravings during the menstrual cycle. After statistical correction, hsCRP remained significant for chocolate, sweet, and salty cravings.

Moderate study design 259 women aged 18 to 44 followed over two menstrual cycles

What they did

Prospective observational study of 259 women aged 18 to 44 followed over two menstrual cycles. Women reported food cravings up to four times per cycle at different phases. Blood samples were collected up to eight times per cycle to measure inflammation markers including hsCRP, GCSF, GMCSF, IL-4, IL-6, RANTES, and MIP1B.

What they found

Multiple inflammation markers showed associations with increased risk of moderate or severe cravings across the menstrual cycle, with all risk ratios greater than 1 and confidence intervals ranging from 0.71 to 2.38. After correction for multiple testing, hsCRP was significant for chocolate, sweet, and salty cravings. GCSF, GMCSF, IL-6, and RANTES were significant for chocolate and sweet cravings only.

What it means for you

Inflammation in the body may contribute to food cravings before the period. The study was fairly large, followed women over multiple cycles, and measured inflammation markers directly, which strengthens the findings.

259

Women studied

2 cycles

Duration per woman

0.71-2.38

Confidence interval range for associations

About the study

Original title
Association of inflammation biomarkers with food cravings and appetite changes across the menstrual cycle
Authors
Agarwal K, Franks AT, Zhang X et al.
Journal
Clinical nutrition ESPEN
Year
2023
Study design
Survey study
Participants
259
What was tested
None
Open access
Yes

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