Cohort study, 1996
Can hormones trigger PMS symptoms in women without ovaries or a uterus?
Not clearly. Some individual women showed links between progesterone and symptoms, but results overall were not statistically significant. Women don't respond uniformly to hormones.
What they did
9 women who had hysterectomy and oophorectomy and previously had severe PMS received estrogen and progesterone in a single-blind study. They completed daily symptom questionnaires and hormone levels were measured.
What they found
Overall, symptom measures did not correlate with hormone levels. However, individual women sometimes showed correlations between symptom scores and progesterone levels.
What it means for you
PMS does not respond the same way to hormones in all women. One hormone mechanism cannot explain PMS in everyone. Limitation: very small sample of only 9 women and results were not statistically significant.
9
women studied
About the study
- Original title
- Can one induce premenstrual symptomatology in women with prior hysterectomy and bilateral oophorectomy?
- Authors
- Henshaw C, Foreman D, Belcher J et al.
- Journal
- Journal of psychosomatic obstetrics and gynaecology
- Year
- 1996
- Study design
- Cohort study
- What was tested
- Estrogen and progesterone
- Read the paper
- doi.org/10.3109/01674829609025660
Topics
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