Case-control study, 2013
Are insulin and leptin levels different in women with PMDD across the menstrual cycle?
Yes. Women with PMDD had different patterns of insulin and leptin changes across the cycle compared to women without PMDD, but it is unclear whether these hormone changes cause mood and appetite symptoms or result from them.
What they did
Researchers studied 20 women with PMDD and 18 women without PMDD. Fasting blood glucose, insulin, leptin, and progesterone levels were measured during the follicular phase (early cycle) and luteal phase (second half of cycle).
What they found
Significant interactions were found for serum leptin, insulin, and HOMA-IR (insulin resistance measure) between PMDD diagnosis and menstrual phases (F = 5.4, p = 0.025 for leptin; F = 5.4, p = 0.026 for insulin; F = 4.7, p = 0.036 for HOMA-IR). In women without PMDD, a significant correlation was found between progesterone and insulin levels in the luteal phase (r = 0.58, p = 0.01).
What it means for you
Insulin and leptin may play a role in PMDD symptoms, but the sample was very small and it remains unclear whether these hormone changes are the cause or result of mood and appetite changes. These findings need larger studies to confirm.
20
women with PMDD
18
women without PMDD
0.025
p-value for leptin interaction
About the study
- Original title
- Circulating insulin and leptin in women with and without premenstrual disphoric disorder in the menstrual cycle
- Authors
- Akturk M, Toruner F, Aslan S et al.
- Journal
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
- Year
- 2013
- Study design
- Case-control study
- Participants
- 20
- What was tested
- Observational comparison of hormone levels across cycle phases
- Read the paper
- doi.org/10.3109/09513590.2013.769512
Topics
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