Review, 1987
How well do hormone-suppressing drugs work for treating gynaecological conditions?
This review suggests that hormone-suppressing drugs called LHRH agonists work well for several gynaecological conditions and have few serious side effects, though larger studies are needed to compare which drugs and doses work best.
What they did
A literature review summarizing clinical studies of LHRH agonist and antagonist drugs (which suppress reproductive hormones) for treating various gynaecological conditions.
What they found
The review reports that LHRH agonists can safely suppress reproductive hormones with quick recovery after stopping. These drugs appear promising for treating precocious puberty, endometriosis, uterine fibroids, polycystic ovary syndrome (PCO), and improving ovulation induction. Nasal administration may work for short-term suppression of up to 28 days. LHRH antagonists were less promising. Combining agonists with other hormone blockers may be even more effective.
What it means for you
Hormone-suppressing drugs may help with certain gynaecological problems by turning down reproductive hormones, but large-scale studies are still needed to know which drugs and doses work best. These drugs are not specifically studied for PMS or PMDD in this review.
28
Maximum days for nasal hormone-suppressing administration
About the study
- Original title
- Clinical applications of LHRH analogues
- Authors
- Fraser HM, Baird DT
- Journal
- Bailliere's clinical endocrinology and metabolism
- Year
- 1987
- Study design
- Review
- What was tested
- LHRH agonist and antagonist drugs
- Read the paper
- doi.org/10.1016/s0950-351x(87)80052-6
Topics
Related studies
Cohort study, 2026
Do early-life exposures like antibiotics or breastfeeding affect PMS risk?
Cohort study, 2006
How should severe period pain in teenagers be treated?
Survey study, 2002
What causes period pain, endometriosis, and PMS in teenage girls, and what treatments work?
Randomised trial, 2026
Does vitamin D help with PMS symptoms?
Cohort study, 2026
Which established risk factors genetically cause premenstrual disorder?
Survey study, 2021
What are the menstrual cycle patterns and how common are PMS and PCOS in young Korean women?