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Randomised trial, 2017

Does lemon balm capsule or educational support work better for reducing PMS symptoms?

Yes, both lemon balm capsules and educational support programs significantly reduced physical, mental, and social PMS symptoms compared to placebo and no treatment. We can be fairly confident because this was a well-designed randomized controlled trial with 200 women tracked over 3 months.

Moderate study design 200 high school girls with PMS in Shiraz, Iran

What they did

Randomized placebo-controlled trial with 200 high school girls with PMS in four groups. One took 600 mg lemon balm daily for entire menstrual cycle for 3 consecutive cycles. One received educational support programs. One took placebo. One received no treatment. Researchers measured symptoms at baseline, 1 month, and 2 months after intervention.

What they found

All treatment groups showed significant reductions in physical, psychological, and social symptoms of PMS at all three measurement times. The control and placebo groups had the least improvement in symptoms over time, with much less change than the treatment groups.

What it means for you

For reducing PMS symptoms, both taking lemon balm supplements and receiving educational support about PMS appear to help. The study was large with 200 women and well-structured with multiple comparison groups. Main limitations are that it only included high school girls in one city in Iran, so results may not apply to all women or different age groups.

600 mg

Daily lemon balm dose

3 cycles

Duration of lemon balm treatment

200

Total number of girls studied

About the study

Original title
Comparison of the Effect of Melissa officinalis Capsule and Care Educational Programs on the Intensity of Physical, Mental and Social Symptoms of Premenstrual Syndrome in High School Female Students
Authors
Marzieh Akbarzadeh, Zeinab Moshfeghy, Mansureh Dehghani et al.
Journal
International Journal of Women s Health and Reproduction Sciences
Year
2017
Study design
Randomised trial
Participants
200
What was tested
Lemon balm capsule 600 mg daily for entire menstrual cycle for 3 consecutive cycles, or care educational programs
Open access
Yes
Original abstract

Objectives: Premenstrual syndrome (PMS) is one of the psychosomatic problems related to women›s reproductive function, which is associated with emotional and mood symptoms such as anger, anxiety and irritability.The current study aimed to compare the effect of Melissa officinalis capsule and care educational programs on the intensity of physical, mental and social aspects of PMS in high school girls. Materials and Methods:This study was a randomized, placebo-controlled trial which was conducted on 200 high school girls with PMS who were randomly allocated into 4 groups in Shiraz.The first group received 600 mg of M. officinalis essence daily from the first to the end day of their menstrual cycle for 3 consecutive cycles; the second and third groups received care educational program and placebo respectively, and the last one was the control group.The data were analyzed using paired t test and Repeated measures analysis of variance (ANOVA). Results:The results of repeated measures ANOVA test revealed a significant reduction in 3 determined times, pre-intervention, one and 2 consecutive months after the intervention (P < 0.001), in the intensity of physical, psychological and social aspects of PMS symptoms, and this varied in different groups (P < 0.001).The extent of changes varied over time and in different groups, so, the control and placebo groups had the least symptom changes over the time Conclusion: Melissa officinalis capsule and care educational programs were much more effective in reduction of the severity of physical, mental and social symptoms of PMS compared to the control and placebo groups.

Reproduced under CC-BY.

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