Non-randomised trial, 1979
Does danazol help premenstrual syndrome?
Half of 12 women with severe PMS benefited. However, a second group had a high dropout rate because side effects outweighed any benefits.
What they did
Tested danazol at doses of 200-800 mg daily in 12 women with severe PMS and at 400 mg daily in a second group of fresh cases as first or second treatment choice.
What they found
Of 12 women with severe symptoms, 6 benefited from treatment. The second group had a high dropout rate and benefits were outweighed by side effects.
What it means for you
Danazol may help severe PMS, especially breast tenderness, but side effects are a major problem. The study was very small with no control group and high dropout in one arm.
12
Women with severe PMS
6
Benefited from danazol (50%)
About the study
- Original title
- Danazol and the premenstrual syndrome
- Authors
- Day J
- Journal
- Postgraduate medical journal
- Year
- 1979
- Study design
- Non-randomised trial
- Participants
- 12
- What was tested
- Danazol 200-800 mg daily (first group), 400 mg daily (second group)
- Read the paper
- https://pubmed.ncbi.nlm.nih.gov/395526/
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