Randomised trial, 2022
Does PMS50 supplementation reduce psychological symptoms of premenstrual syndrome?
Yes, it helped several psychological symptoms like mood, anxiety, and irritability compared to placebo. The study was small, so we need larger trials to be sure.
What they did
Double-blind randomized trial where 50 university students in Iran with moderate to severe PMS took either 550 mg per day of PMS50 or placebo for one week before their period until the end of their period, for three consecutive cycles. Researchers measured psychological symptoms before and after.
What they found
The PMS50 group had significant improvements in depression, anger, hopelessness, desire to be alone, mood swings, irritability, anxiety, and poor concentration compared to placebo. Restlessness decreased in both groups equally. Low self-esteem, appetite changes, and food cravings dropped in both groups but were not significantly different between them.
What it means for you
PMS50 may help mood and anxiety symptoms, but the study was small (25 women per group) and conducted in one country, so results may not apply to everyone.
25
women in treatment group
25
women in placebo group
3
consecutive menstrual cycles
About the study
- Original title
- Effects of PMS50 supplementation on psychological symptoms of students with premenstrual syndrome
- Authors
- Sadeghi F, Javid AZ, Nazarinasab M et al.
- Journal
- International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
- Year
- 2022
- Study design
- Randomised trial
- Participants
- 25
- What was tested
- 550 mg per day of PMS50
- Read the paper
- doi.org/10.1002/ijgo.13703
Topics
Related studies
Study, 2026
What are premenstrual syndrome and premenstrual dysphoric disorder?
Randomised trial, 2021
Does hypnotherapy reduce pain and emotional distress in women with PMDD?
Randomised trial, 1995
Is paroxetine better than other antidepressants for treating severe PMS?
Survey study, 2026
Does eating more ultra-processed food make PMS symptoms worse?
Survey study, 2026
How common is PMDD in Russian medical students, and what are its symptoms?
Survey study, 2017
Are PMS symptoms linked to mood disorders and personality?