Review, 2012
Do GnRH agonist drugs treat PMS?
Yes, GnRH agonist drugs can completely abolish PMS symptoms. However, they cause significant side effects from lowered estrogen that can be managed with add-back therapy.
What they did
Review article updating evidence on GnRH agonists combined with add-back therapy for treating PMS and other hormone-dependent conditions.
What they found
GnRH agonists can completely abolish PMS symptoms. They are also effective for endometriosis and as adjuvant therapy for fibroids. Side effects from the low-estrogen state limited their previous use, but add-back therapy allows for wider application, longer treatment duration, and better patient compliance.
What it means for you
GnRH agonist drugs can eliminate PMS symptoms but cause significant side effects from low estrogen. Add-back therapy helps manage these side effects. This is a review of existing evidence rather than new research, and the abstract does not provide specific outcome details.
About the study
- Original title
- Gonadotrophin receptor hormone analogues in combination with add-back therapy: an update
- Authors
- McLaren JS, Morris E, Rymer J
- Journal
- Menopause international
- Year
- 2012
- Study design
- Review
- What was tested
- GnRH agonist drugs combined with add-back therapy
- Read the paper
- doi.org/10.1258/mi.2012.012008
Topics
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