Review, 1987
What medicines work best for treating moderate to severe premenstrual syndrome?
For mild to moderate PMS, the first approach should be diet, exercise, and nutritional supplements. For severe cases, medications like danazol, estrogen implants, or progesterone at 300 mg per day can be tried, though evidence for some is still limited.
What they did
This was a review of medication treatment options for different levels of PMS severity.
What they found
Progesterone alone did not work better than placebo in most studies, except one study using oral micronized progesterone at 300 mg per day. Other options with some evidence include danazol, estrogen implants, depomedroxyprogesterone acetate, and prostaglandin inhibitors.
What it means for you
Treatment should match symptom severity. A major limitation is that much evidence comes from small studies and some treatments need further testing by other researchers.
300 mg/day
Dose of oral micronized progesterone that showed benefit in one study
About the study
- Original title
- Indications for drug therapy in premenstrual syndrome patients
- Authors
- Chihal HJ
- Journal
- The Journal of reproductive medicine
- Year
- 1987
- Study design
- Review
- What was tested
- Various medications including progesterone, danazol, estrogen, and others
- Read the paper
- https://pubmed.ncbi.nlm.nih.gov/2956417/
Topics
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