Case report, 1999
Can the antidepressant nefazodone trigger mania in someone with undiagnosed bipolar disorder?
In this one reported case, a patient likely developed mania after starting nefazodone, suggesting the drug may be able to trigger mania, but a single case cannot prove this happens generally.
What they did
This was a report describing a single patient who developed symptoms of mania while being treated with the antidepressant nefazodone, and who had not previously been diagnosed with bipolar disorder. The report also discussed ideas about how this might have happened.
What they found
The patient's mania was judged to be probably caused by the nefazodone treatment. The report notes that only one other case of mania linked to this drug had been published before this one.
What it means for you
Because this is based on a single patient with no comparison group, it cannot prove that nefazodone generally causes mania. It may still be useful as a warning for doctors to watch for mania, especially in people who might have unrecognized bipolar disorder.
1
previously published similar case
About the study
- Original title
- Micronized progesterone: a new option for women's health care
- Authors
- Wetzel W
- Journal
- The Nurse practitioner
- Year
- 1999
- Study design
- Case report
- What was tested
- The antidepressant nefazodone
- Read the paper
- doi.org/10.1097/00006205-199905000-00005
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