Review, 1987
Can progesterone tablets help PMS?
Oral micronized progesterone appears suitable for treating PMS, with no reported side effects on heart health factors tested. However, this is a review, not a clinical trial proving it works.
What they did
The authors reviewed the bioavailability, pharmacology, and therapeutic applications of oral micronized progesterone.
What they found
Oral micronized progesterone was developed to solve the problem of liver inactivation that prevented earlier forms of progesterone from working by mouth. At 200 mg daily, the preparation reproduces the anti-estrogenic effect of natural progesterone on the endometrium and its anti-mineralocorticoid effect. No side effects were reported regarding lipids profile, coagulation factors, or blood pressure.
What it means for you
Progesterone tablets might help PMS without increasing risks to the heart or blood clotting. However, this is a review describing potential use, not a clinical study showing it actually reduces PMS symptoms. The dose discussed is 200 mg daily.
200 mg
Daily dose reproducing anti-estrogenic effect
About the study
- Original title
- Oral micronized progesterone. Bioavailability pharmacokinetics, pharmacological and therapeutic implications--a review
- Authors
- Sitruk-Ware R, Bricaire C, De Lignieres B et al.
- Journal
- Contraception
- Year
- 1987
- Study design
- Review
- Read the paper
- doi.org/10.1016/0010-7824(87)90088-6
Topics
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