Randomised trial, 2013
Is buspirone as good as fluoxetine for treating PMS?
Both medicines helped reduce PMS symptoms, and there was no clear difference between them. However, larger and more rigorous studies are needed to confirm this.
What they did
100 women with PMS were randomly divided into two groups. One took fluoxetine 20 mg per day; the other took buspirone 10 mg per day. Both took their medicine for 2 months. Women reported symptoms before treatment started, after 1 month, and after 2 months. This was a single-blind study.
What they found
Both fluoxetine and buspirone were effective at reducing PMS symptoms during the 2-month treatment period. There was no clear difference in how well they worked.
What it means for you
Buspirone and fluoxetine may both help with PMS, and buspirone might be useful because it has fewer side effects. This study was small, single-blind, and had no placebo control group. Larger double-blind studies are needed to confirm these findings.
100
Women studied
20 mg daily
Fluoxetine dose
10 mg daily
Buspirone dose
About the study
- Original title
- Premenstrual syndrome: a single-blind study of treatment with buspirone versus fluoxetine
- Authors
- Nazari H, Yari F, Jariani M et al.
- Journal
- Archives of gynecology and obstetrics
- Year
- 2013
- Study design
- Randomised trial
- What was tested
- Fluoxetine 20 mg daily or buspirone 10 mg daily for 2 months
- Read the paper
- doi.org/10.1007/s00404-012-2594-x
Topics
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