Randomised trial, 1991
Does higher progesterone dose work better for PMS?
No. The researchers found that symptoms improved in both the progesterone group and placebo group when more suppositories were given, suggesting higher doses do not add extra benefit.
What they did
This is a response to criticism of the authors' earlier progesterone study. They reviewed findings from a placebo-controlled trial using 400-mg progesterone suppositories and measured blood progesterone levels.
What they found
Symptoms decreased for both the progesterone group and placebo group when the number of suppositories was increased.
What it means for you
Since both groups improved together with more treatment, this suggests improvement may not be due to progesterone itself. Higher doses may not be more effective than lower doses. Main limits: reply letter with incomplete information.
400 mg
dose of suppositories
About the study
- Original title
- Premenstrual Syndrome and Progesterone Suppositories-Reply
- Authors
- Ellen W. Freeman
- Journal
- JAMA
- Year
- 1991
- Study design
- Randomised trial
- What was tested
- Progesterone suppositories 400-mg
- Read the paper
- doi.org/10.1001/jama.1991.03460010026012
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