Does a birth control pill with estetrol and drospirenone help PMS?

The objective: to study the effectiveness of a drug containing estetrol (Е4) and drospirenone in the treatment of patients with premenstrual syndrome (PMS) and its impact on hormonal homeostasis, mental health, and quality of life.Materials and methods. 78 patients with PMS were divided into 2 groups: comparison group – 46 women who received non-hormonal therapy for 3 months and study group – 32 patients who used a drug containing Е4 and drospirenone for 3 months. Control group consisted of 118 healthy women. All patients were examined before and after treatment. The levels of serotonin, prolactin, follicle stimulating hormone, luteinizing hormone, cortisol, estradiol, progesterone in blood serum were determined; in daily urine – dopamine, adrenaline, noradrenaline; mental health and quality of life were studied.Results. In the comparison group, after therapy, the percentage of increased irritability/aggression significantly decreased and the dopamine level significantly increased and the levels of estradiol, adrenaline, noradrenaline, cortisol and perceived stress significantly decreased. In the study group, most of PMS clinical manifestations significantly decreased and the levels of all hormones significantly increased compared to the initial data and approached the results of the control group. Also, the indicators of neuroticism, depression and integral assessment of asthenia significantly decreased and the quality of life improved.Conclusions. In patients with PMS, before treatment, significant disorders in the homeostasis of the hormonal system were found; indicators of stress, neuroticism, asthenia and depression increased significantly and quality of life – decreased. Three-month therapy with non-hormonal drugs did not allow to restore the clinical, hormonal and mental state of women with PMS. The use of a drug containing Е4 and drospirenone in the treatment of PMS patients for 3 months significantly improved the patient’s state and hormonal level and led the indices closer to the results in the control group, which contributed to the normalization of mental health and quality of life of patients in this cohort.

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