Case-control study, 2007
Does a genetic variant in the serotonin receptor gene affect PMDD risk?
A genetic variant (the C version) was more common in women with PMDD. Having at least one C version was associated with increased PMDD risk, though evidence was borderline.
What they did
Researchers examined a specific genetic variation in 53 women with PMDD (average age 37.7 years) and 51 healthy controls (average age 36.2 years), comparing which genetic versions they carried.
What they found
The C/C genetic version was much more common in PMDD patients than controls. Having at least one C allele appeared to increase the risk of PMDD, though this finding was borderline.
What it means for you
A genetic variant may increase PMDD risk, though the finding was borderline and opposite to expectations. This small study needs confirmation in larger groups.
53
Women with PMDD
51
Healthy control women
37.7 years
Average age of PMDD group
About the study
- Original title
- Serotonin receptor 1A C(-1019)G polymorphism associated with premenstrual dysphoric disorder
- Authors
- Dhingra V, Magnay JL, O'Brien PM et al.
- Journal
- Obstetrics and gynecology
- Year
- 2007
- Study design
- Case-control study
- Participants
- 53
- What was tested
- None; observational genetic comparison study
- Read the paper
- doi.org/10.1097/01.aog.0000284448.73490.ac
Topics
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