Case-control study, 1981
Is sex hormone-binding globulin (SHBG) different in women with severe PMS?
Yes. Women with severe PMS have significantly lower SHBG binding capacity. This suggests low SHBG may help explain PMS and could be useful for diagnosis.
What they did
Case-control study measuring SHBG binding capacity in 50 women with severe PMS and 50 age-matched control women.
What they found
Women with severe PMS had significantly lower SHBG binding capacity compared to controls.
What it means for you
Low SHBG may help explain what causes PMS and could be used as a diagnostic test. However, this is a single study and needs to be repeated in larger groups of women.
50
women with severe PMS
50
age-matched control women
P = 0.001
difference was statistically significant
About the study
- Original title
- Sex hormone-binding globulin concentrations in women with severe premenstrual syndrome
- Authors
- Dalton ME
- Journal
- Postgraduate medical journal
- Year
- 1981
- Study design
- Case-control study
- Participants
- 50
- Open access
- Yes
- Read the paper
- doi.org/10.1136/pgmj.57.671.560
Topics
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