Cohort study, 2020
Do cells from women with PMDD respond differently to hormones?
Yes. Cells from women with PMDD show unusual patterns of gene and protein expression in a hormone-sensing complex called ESC/E(Z). This is early laboratory research, not yet tested in people.
What they did
Researchers compared cell cultures from women with PMDD and healthy women. They looked at which genes were active before and after adding female hormones estradiol and progesterone.
What they found
In untreated cells, women with PMDD had more copies of genes in the ESC/E(Z) complex but less protein. Three genes (MTF2, PHF19, SIRT1) showed the biggest changes. In healthy controls, progesterone increased certain genes, while in PMDD cells, estradiol decreased them.
What it means for you
Women with PMDD may have cells that process hormones abnormally, which could explain their sensitivity to hormone shifts. This is very early lab work and does not yet suggest treatments, but it points researchers toward understanding PMDD better.
13
ESC/E(Z) complex genes analyzed
3
genes with biggest changes (MTF2, PHF19, SIRT1)
Over half
ESC/E(Z) genes over-expressed in PMDD cells
About the study
- Original title
- The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder
- Authors
- Yuan, Martinez, Goldman et al.
- Journal
- Carolina Digital Repository (University of North Carolina at Chapel Hill)
- Year
- 2020
- Study design
- Cohort study
- What was tested
- None
- Open access
- Yes
- Read the paper
- doi.org/10.17615/hbrz-mb46
Topics
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