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Cohort study, 2023

What medications and supplements treat PMDD?

SSRIs are the first-line medication. Combined oral contraceptives and Chasteberry are second-line options. Certainty varies by treatment type.

Early or limited evidence Women with PMDD (expert review summarizing evidence across populations)

What they did

An expert review summarizing current knowledge about PMDD's causes, symptoms, diagnosis, and pharmacological treatment.

What they found

SSRIs are established first-line treatment. Accurate diagnosis requires prospective daily symptom tracking for at least two menstrual cycles. Combined monophasic oral contraceptives are second-line. Chasteberry extract shows efficacy in mild-to-moderate cases. Compounds blocking allopregnanolone synthesis show preliminary promise.

What it means for you

These are expert recommendations based on existing evidence about how to treat PMDD. Individual response varies. The main limitation is that this is expert opinion summarizing other research, not new primary data.

2

Minimum menstrual cycles of daily symptom tracking needed for accurate PMDD diagnosis

About the study

Original title
The pharmacotherapeutic management of premenstrual dysphoric disorder
Authors
Ciccone N, Kovacheff MB, Frey BN
Journal
Expert opinion on pharmacotherapy
Year
2023
Study design
Cohort study
What was tested
Not applicable; this is an expert review, not a treatment trial

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