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Survey study, 2026

Is there a link between PMS symptom severity and daily stress hormone levels?

Women who reported worse PMS symptoms had lower cortisol (stress hormone) levels during the day. Cortisol patterns varied slightly across cycle phases, suggesting stress hormones may play a role in PMS, though this was a very small study.

Early or limited evidence 15 healthy women aged 18-31 years.

What they did

Researchers measured salivary cortisol in 15 women at four times after waking and three times during the day during three different cycle phases. Women reported how severe their symptoms felt and completed anxiety and sleep questionnaires.

What they found

Cortisol levels were higher during the menstrual phase than the luteal and premenstrual phases. Women with higher symptom severity had lower cortisol during the day (correlation of -0.648). Women with high trait anxiety had lower cortisol during their period and premenstrual phases.

What it means for you

This small study with only 15 women measured each woman for only one cycle, so we cannot be confident these findings apply to everyone. It suggests stress hormones may be involved in PMS, but the relationship is not fully understood.

15

women studied

-0.648

correlation of problem severity with cortisol

3

cycle phases measured

About the study

Original title
The Relationship Between Perceived Premenstrual Symptoms and Salivary Cortisol Levels in Women with Premenstrual Syndrome
Authors
Tuba Özgöçer, Cihat Uçar, Sedat Yıldız
Journal
Dynamic Medical Theories
Year
2026
Study design
Survey study
Participants
15
What was tested
Cortisol testing during menstrual cycle phases, no intervention.
Open access
Yes

Topics