Survey study, 1994
Do different types of progestogen cause different types of symptoms?
Yes. Norethisterone causes more pain symptoms but fewer mood problems, while medroxyprogesterone and dydrogesterone show the opposite pattern.
What they did
Cross-sectional study of women taking hormone replacement therapy with cyclical progestogen. Symptoms were assessed using a standardized questionnaire.
What they found
Different progestogens caused different symptom patterns. Norethisterone was more likely to cause pain, while medroxyprogesterone and dydrogesterone were less likely to cause pain but more likely to cause mood and behavioral changes.
What it means for you
The type of progestogen a woman takes affects which symptoms she experiences. However, this was an observational study without a control group, so we cannot be certain the drug type caused the symptom differences.
About the study
- Original title
- The symptomatology of progestogen intolerance
- Authors
- Smith RN, Holland EF, Studd JW
- Journal
- Maturitas
- Year
- 1994
- Study design
- Survey study
- What was tested
- Exposure to different types of progestogen
- Read the paper
- doi.org/10.1016/0378-5122(94)90046-9
Topics
Related studies
Systematic review, 2023
What hormonal treatments have been tested for PMDD, menstrual migraine, and catamenial epilepsy?
Survey study, 2022
What causes PMS and PMDD and what new treatments are being studied?
Systematic review, 2015
What are the effects of continuous hormonal treatments for premenstrual syndrome?
Review, 2012
How should premenstrual disorders be diagnosed and organized?
Review, 2012
How is PMS diagnosed and treated, especially in women approaching menopause?
Randomised trial, 2012
Do hysterectomy or hormonal IUDs reduce premenstrual symptoms in women with heavy periods?