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Randomised trial, 2007

Does the birth control pill containing drospirenone and ethinyl estradiol help treat PMDD?

The limited research available suggests it may help, and the pill has good tolerability and other health benefits, but more studies are needed to be sure.

Early or limited evidence Women with PMDD (review of clinical trials)

What they did

Reviewed recently published placebo-controlled randomized studies testing the birth control pill containing drospirenone and ethinyl estradiol for treating PMDD.

What they found

Several placebo-controlled randomized studies tested this pill combination for PMDD treatment. The results of these trials were encouraging. The pill offers high contraceptive efficacy, good cycle control, good tolerability, and a favorable impact on lipid and glucose metabolism.

What it means for you

The evidence so far suggests this pill may be helpful for PMDD and may offer benefits beyond symptom relief. However, this is a review of existing research rather than a new study, and the review emphasizes that further studies are needed before firm conclusions can be drawn.

About the study

Original title
Treatment of premenstrual dysphoric disorder (PMDD) with a novel formulation of drospirenone and ethinyl estradiol
Authors
De Berardis D, Serroni N, Salerno RM et al.
Journal
Therapeutics and clinical risk management
Year
2007
Study design
Randomised trial
What was tested
Drospirenone-ethinylestradiol as combined oral contraceptive for PMDD
Open access
Yes

Topics