Cohort study, 1996
Does lisuride maleate, a dopamine medication, reduce PMS symptoms?
Symptoms improved significantly, with headaches dropping from 85.7% to 20% and other symptoms also improving. However, this was a small study with no control group, so we cannot be sure how much improvement came from the drug versus placebo.
What they did
35 women aged 19-35 with PMS and no other gynecological disorders were treated with lisuride maleate 0.3 mg daily (split into 3 doses) for 3 months. Researchers measured symptom severity and hormone levels before and after treatment.
What they found
All measured symptoms improved significantly: headaches from 85.7% to 20%, breast pain from 91.4% to 25%, bloating from 74.2% to 40%, lower leg swelling from 85.7% to 30%, and leg pain from 61% to 34%. Hormone levels showed small changes in FSH, progesterone, and prolactin.
What it means for you
Lisuride maleate produced large symptom reductions. However, without a control group we cannot know if improvements came from the drug or from placebo or time alone. Adverse events were reported by 20 patients, and 1 withdrew early due to fatigue and headache. Hormone levels were only measured at one time point, so it is unclear how hormones actually changed.
85.7% to 20%
headache reduction
91.4% to 25%
breast pain reduction
74.2% to 40%
bloating reduction
About the study
- Original title
- [Treatment of premenstrual tension syndrome (PMS) with lisuride maleate]
- Authors
- López-Rosales C, Aguilar-Guerrero JA, García-Moreno L
- Journal
- Ginecologia y obstetricia de Mexico
- Year
- 1996
- Study design
- Cohort study
- Participants
- 35
- What was tested
- Lisuride maleate 0.3 mg daily for 3 months (dopamine receptor agonist)
- Read the paper
- https://pubmed.ncbi.nlm.nih.gov/9019440/
Topics
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