Randomised trial, 2019
Does vitamin D supplementation improve inflammation markers and PMS?
Yes. Vitamin D supplementation improved inflammation markers and total PMS symptom scores in vitamin D-deficient women.
What they did
44 vitamin D-deficient women with PMS received vitamin D supplementation. Researchers measured inflammation markers (IL-10, IL-12) and antioxidant capacity (TAC) before and after treatment.
What they found
After vitamin D supplementation, IL-10 and IL-12 levels significantly decreased and total antioxidant capacity significantly increased. Overall PMS symptom scores significantly improved, with significant differences between groups for IL-12 and TAC.
What it means for you
Vitamin D may help PMS by reducing inflammation and improving the body's antioxidant system. This is a small study with limited detail about dosage and duration in the abstract, so findings need confirmation in larger studies.
44
Women in study
IL-10, IL-12
Inflammation markers decreased
TAC
Antioxidant capacity increased
About the study
- Original title
- Vitamin D Supplementation for Premenstrual Syndrome-Related inflammation and antioxidant markers in students with vitamin D deficient: a randomized clinical trial
- Authors
- Heidari H, Amani R, Feizi A et al.
- Journal
- Scientific reports
- Year
- 2019
- Study design
- Randomised trial
- What was tested
- Vitamin D supplementation (dose and duration not specified)
- Open access
- Yes
- Read the paper
- doi.org/10.1038/s41598-019-51498-x
Original abstract
Premenstrual syndrome (PMS) is a common disorder in the reproductive age that negatively significant impacts on women's quality of life. This randomized clinical trial study was undertaken to investigate the effect of vitamin D supplementation on inflammatory and antioxidant markers in 44 vitamin D deficient (25(OH)D 3 , Interleukin10 and 12 (IL-10, IL-12) and total antioxidant capacity (TAC). In vitamin D group, serum levels of IL-10 and IL-12 significantly decreased while TAC significantly increased post-intervention. There were significant differences regarding serum IL-12 and TAC levels between the two groups. Mean score of the total PMS symptoms showed significant improvement in 25(OH)D. Vitamin D supplementation seems to be an effective strategy to improve inflammation and antioxidant markers in vitamin D deficient women with PMS. This clinical trial was registered at Iranian Registry of Clinical Trials on 20/06/2018 (IRCT20180525039822N1).
Reproduced under CC-BY.
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