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Randomised trial, 2025

Does fenugreek seed extract reduce PMS symptoms?

In this pilot study, fenugreek reduced PMS symptom scores by an average of 32% and was well tolerated. However, there was no control group, so the improvement could be due to placebo effect.

Early or limited evidence 10 women aged 20-35 with moderate-to-severe PMS

What they did

Open-label pilot study of 10 women aged 20-35 with moderate-to-severe PMS. Each received 500 mg of standardized fenugreek extract daily for 2 menstrual cycles. PMS symptoms were measured before and after using the Moos Menstrual Distress Questionnaire.

What they found

By the end of 2 cycles, participants had an average 32% reduction in symptom scores. The most notable improvements were in irritability, breast tenderness, and fatigue. No serious adverse effects were reported.

What it means for you

Fenugreek may help some PMS symptoms, particularly irritability and breast tenderness, and appears safe. This was a very small pilot with no control group or placebo comparison, so improvement could be due to placebo effect. Larger controlled trials are needed.

10

Participants

500 mg/day

Fenugreek extract dose

32%

Average symptom score reduction

About the study

Original title
Effect of 50% Saponin-Standardized Fenugreek Extract on Free Testosterone: An 8-Week Randomized Controlled Trial
Authors
Ramana Krishnan, Kavitha PS
Journal
International Journal For Multidisciplinary Research
Year
2025
Study design
Randomised trial
What was tested
500 mg daily fenugreek seed extract standardized to 50% saponin
Open access
Yes
Original abstract

Background: Premenstrual syndrome (PMS) is a common and often disruptive condition affecting many women’s physical and emotional wellbeing. Fenugreek seed extract, known for its traditional medicinal use, may offer a natural alternative for relief due to its hormonal and anti-inflammatory properties. Objective: To explore the effects of a 500 mg daily dose of fenugreek seed extract on PMS symptoms over two menstrual cycles. Methods: Ten women aged 20–35 years with moderate-to-severe PMS participated in a single-arm, open-label pilot study. Each received 500 mg of standardized fenugreek extract daily. PMS symptoms were evaluated before and after the intervention using the Moos Menstrual Distress Questionnaire (MDQ). Results: By the end of two cycles, participants showed an average 32% reduction in MDQ scores. The most notable improvements were seen in irritability, breast tenderness, and fatigue. No serious adverse effects were reported. Conclusion: Fenugreek seed extract appears to be a safe and promising option for alleviating PMS symptoms. These encouraging results warrant further investigation in larger, controlled trials.

Reproduced under CC-BY-SA.

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