Can plant-based supplements help with PMS and breast health?

Women of reproductive age require effective and safe treatments for the prevention of breast diseases, including benign mammary dysplasia (BMD), as well as for alleviating symptoms associated with premenstrual syndrome (PMS). Objective. This study aims to organize information regarding the pharmacological effects and safety profiles of plant extracts utilized in the management of breast diseases, PMS, hormonal imbalances, and functional disorders of the genitourinary system. Materials and Methods. A comprehensive search was performed for studies examining the properties of cinnamon rose extract, bearberry extract, oregano extract, milk thistle extract, ortilia secunda extract, sweetvetch extract, purple echinacea extract, and their combinations. This search utilized the validated bibliographic database of the US National Library of Medicine PubMed, as well as the Russian scientific online libraries eLibrary and Cyberleninka, and the websites of prominent regulatory agencies. Results. The plant extracts incorporated in dietary supplements (DS) exhibit antiproliferative, antitumor, antioxidant, analgesic, anti-inflammatory, and antiseptic properties, as evidenced by both in vitro and in vivo studies. The concentrations of arbutin, flavonols (expressed as rutin), flavonolignans, hydroxycinnamic acids, and tannins (expressed as tannin) present in the daily dosage of the DS are deemed safe for human consumption. Conclusion. The synergistic application of cinnamon rose extract, bearberry extract, oregano extract, milk thistle extract, ortilia secunda extract, sweetvetch extract, and purple echinacea extract may yield beneficial effects for women suffering from bone mineral density (BMD) issues and premenstrual syndrome (PMS) by addressing the underlying pathogenesis and symptoms associated with these conditions. Additionally, it may enhance the functional status of the genitourinary system and improve hormonal profiles. When utilized in accordance with the provided guidelines, this dietary supplement demonstrates a favorable safety profile.

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