Review, 2001
Does serotonin dysfunction play a role in PMDD?
Evidence suggests serotonin dysfunction is involved in PMDD. Medications that increase serotonin, particularly fluoxetine, help reduce PMDD symptoms and have been approved by the US Food and Drug Administration for this purpose.
What they did
Reviewed existing research studies on how serotonin relates to PMDD and how treatments that affect serotonin work.
What they found
Most evidence points to serotonin dysfunction in PMDD. Treatments that enhance serotonin are helpful in reducing symptoms. Fluoxetine, a medication that increases serotonin, has been approved by the US Food and Drug Administration for PMDD.
What it means for you
Serotonin dysfunction appears to play a key role in PMDD, which is why serotonin-increasing medications can help. This conclusion is based on a review of existing studies rather than new research findings.
About the study
- Original title
- The role of central serotonergic dysfunction in the aetiology of premenstrual dysphoric disorder: therapeutic implications
- Authors
- Parry BL
- Journal
- CNS drugs
- Year
- 2001
- Study design
- Review
- What was tested
- None - review article
- Read the paper
- doi.org/10.2165/00023210-200115040-00003
Topics
Related studies
Systematic review, 2024
What are the best treatments for PMDD and PMS?
Review, 2024
What are the most effective treatments for PMDD?
Systematic review, 2024
Do SSRI antidepressants help treat PMS and PMDD?
Randomised trial, 2023
Does taking sertraline when PMDD symptoms start improve how well women function?
Guideline, 2023
How are GnRH agonists used to treat PMDD that doesn't respond to standard medications?
Review, 2022
What causes severe PMS and what treatments work?