Randomised trial, 1989
Does danazol help severe PMS symptoms?
Yes, most PMS symptoms improved more with danazol than placebo, though there were minor side effects. A double-blind controlled study provides good evidence.
What they did
Double-blind placebo controlled crossover study. Women tracked symptoms daily using the Moos menstrual distress questionnaire over multiple cycles.
What they found
Most common premenstrual symptoms improved more with danazol 400 mg/day than with placebo. Treatment was effective despite minor side effects.
What it means for you
Danazol can help severe PMS symptoms, but the abstract does not specify sample size or total study duration.
400
mg/day danazol dose
About the study
- Original title
- Treatment of the premenstrual syndrome: A double blind placebo controlled cross over study using danazol
- Authors
- David H. Gilmore, Robert J. S. Hawthorn, D. M. Hart
- Journal
- Journal of Obstetrics and Gynaecology
- Year
- 1989
- Study design
- Randomised trial
- What was tested
- Danazol 400 mg/day versus placebo
- Read the paper
- doi.org/10.3109/01443618909151073
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