Stopped early
CLEAR-4: Neurocognitive Mechanisms of Perimenstrual Estrogen Effects on Suicidality
Clarifying the Endocrinology of Acute Risk 4 (CLEAR-4): Neurocognitive Mechanisms of Perimenstrual Estrogen Effects on Suicidality
- Status
- Stopped early
- Registry ID
- NCT06191289
- Type
- Interventional (tests a treatment)
- Phase
- Phase 2
- Conditions
- Suicide
- What is tested
- Transdermal Estradiol (drug); Placebo (other)
- Sponsor
- University of Illinois at Chicago
- Where
- United States
- Participants
- 11
- Start
- 2024-03-16
- Completion
- 2024-12-01
- Last update
- 2025-10-29
About the study
This within-person, crossover, 2-condition, placebo-controlled study compares the impact of two perimenstrual conditions on severity of suicidal symptoms in females with past-month suicidality but minimal risk of imminent suicide attempt. The two conditions are (1) perimenstrual administration of estradiol and (2) natural perimenstrual withdrawal from estradiol during placebo.
Summary from ClinicalTrials.gov.